Nature Made SAM-e Complete 400 mg., 60 Tablets Exp. 06/23

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Nature Made® SAM-e Complete®** 400 mg can help replenish your SAM-e levels and help support a healthy mood. Nature Made is the #1 best-selling brand of SAM-e supplements. It’s backed by our satisfaction guarantee, and you will receive your money back if you find that it does not work for you.

  • 400 mg of SAM-e (S-adenosylmethionine Tosylate Disulfate)
  • Helps support a healthy mood in as little as 7-14 days when taken daily
  • Helps support joint comfort
  • May help support muscle comfort & liver function
  • #1 Pharmacist Recommended Vitamin & Supplement Brand*

Factors such as age, certain health conditions and poor diet can impact the amount of SAM-e found in the body.

SAM-e, or S-adenosylmethionine, is a compound naturally produced in the body that may increase levels of neurotransmitters, or brain chemicals, responsible for mood.†1 ,2 When levels are low, a SAM-e supplement can help restore the body’s supply of SAM-e.

Therefore, SAM-e is recommended to help support a healthy mood. SAM-e has been shown to work in as little as 7 to 14 days when taken daily as directed. However, if you are experiencing symptoms of a low mood, see a physician for proper guidance.

SAM-e helps support joint comfort.†,3 SAM-e provides a source of dietary sulfur, which plays a role in joint support. Sulfur is a mineral used by the body in connective tissue and joint cartilage.

Although generally considered as safe, SAM-e has not been evaluated in children or pregnant or lactating women. People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take any product containing SAM-e except under a doctor's supervision.

SAM-e should not be used when taking St. John's Wort. SAM-e should be used with caution and only under your healthcare provider's supervision when taking MAOI drugs, like Marplan, Nardil, Parnate, Manerix. Individuals on other medications should consult their primary healthcare provider prior to starting SAM-e to check for other potential interactions.


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